Composition:
Each Gluconormet (2 mg/ 500 mg) contains glimepiride 2 mg and metformin hydrochloride 500 mg.
Description:
Gluconormet is an oral antidiabetic agent (glimepiride & metformin HCl) used in the management of type 2 diabetes.
Glimepiride: Glimepiride (sulphonyl urea class), mechanism of action appears to be dependent on stimulating the release of insulin from functioning pancreaticbeta cells.
Metformin HCl: Metformin improves glucose tolerance in patients with type 2 diabetes,lowering both basal and postprandial plasma glucose.
Indications:
Gluconormet is indicated in the treatment of patients with type 2 diabetes mellitus when diet, exercise and single agent do not result in adequate glycemic control.
Dosage:
Gluconormet should be given once daily with full meal preferably in the evening. Therapy should be started with Gluconormet (glimepiride 1 mg & metformin 500 mg) one tablet daily. Depending upon the glycemic control, dose may be titrated to 2 tablets once daily.
Alternatively, the therapy may be started with Gluconormet (glimepiride 2 mg & metformin hydrochloride 500 mg) one tablet daily. Depending upon the glycemic control, dose may be titrated to 2 tablets once daily. The maximum daily dose of glimepiride is 8 mg and of metformin is 2000 mg.