Melatonin is an endogenous hormone produced by the pineal gland. It is associated with many biological functions, namely, the modulation of circadian and seasonal rhythms, sleep inducer, a regulator of energy metabolism, antioxidant, and anti-carcinogenic. Although several pieces of evidence also recognize the influence of melatonin in reproductive physiology.
PHARMACODYNAMICS:
The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. MT1 and MT2 receptors may be a target for the treatment of several disorders because of their differences in pharmacology and function.
MECHANISM OF ACTION:
Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cyclase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phospholipase C. This potentiates the release of arachidonate. By binding to melatonin receptors 1 and 2, the downstream signaling cascades have various effects in the body. The melatonin receptors are G protein-coupled receptors and are expressed in various tissues of the body.
INSTRUCTIONS:
Store in a cool & dry place below 30°c.
Protect from light, heat and moisture.
Keep out of reach of children.
Food Supplements/Nutraceuticals/Nutritional Supplements – Not for the treatment of any disease.