Composition:
Each tablet contains 15 mg pioglitazone hydrochloride with 500 mg metformin hydrochloride.
Description:
Pozemet tablet contains two oral antihyperglycemic drugs, pioglitazone hydrochloride and metformin hydrochloride. They are used in the management of type 2 diabetes.
Pioglitazone hydrochloride acts primarily by decreasing insulin resistance. It improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. It reduces circulating insulin levels and improves glycemic control.
Metformin hydrochloride improves glucose tolerance by lowering both basal and postprandial plasma glucose. It improves insulin sensitivity by increasing peripheral glucose uptake and utilization. It also decreases hepatic glucose production and intestinal absorption of glucose.
Indications:
Pozemet is indicated as an adjunct to diet and exercise to improve glycemic control in type 2 diabetic patients who are already treated with a combination of pioglitazone and metformin or whose diabetes is not adequately controlled with metformin alone or for those patients who have initially responded to pioglitazone alone and require additional glycemic control.
Dosage:
Starting dose of Pozemet should be based on the patient’s current treatment of pioglitazone and/or metformin. Pozemet should be given with meals in divided daily doses to reduce the gastrointestinal side effects associated with metformin.
Starting Dose:
For patients inadequately controlled on metformin monotherapy:
Pozemet may be initiated at either 15 mg/500 mg or 15 mg/850 mg tablet strength based on usual starting dose of pioglitazone (15-30 mg daily), once or twice daily and gradually titrated after assessing adequacy of therapeutic response.
For patients who initially responded to pioglitazone monotherapy & require additional glycemic control:
Pozemet may be initiated at either 15 mg/500 mg twice daily or 15 mg/850 mg tablet strength once daily based on the usual starting doses of metformin (500 mg twice daily or 850 mg daily) and gradually titrated after assessing adequacy of therapeutic response.
For patients switching from combination therapy of pioglitazone plus metformin as separate tablets:
Pozemet may be initiated with either 15 mg/500 mg or 15 mg/850 mg tablet strengths based on the dose of pioglitazone and metformin already being taken.
Maximum Recommended Dose:
The maximum recommended dose for pioglitazone is 45 mg & metformin is 2,550 mg daily in adults.
DISCLAIMER
Super Health’s intention is to make sure that its consumers get information that is accurate, reviewed by an expert, and error-free. However, the information mentioned here should not be used as a replacement for the advice of a qualified physician. The information given here is for informational purposes only, and may not cover all possible precautions, side effects, contraindications, or drug interactions. Consult your doctor and discuss your queries related to any medicine or disease.